The results revealed that flow cytometry successfully fractionates rat mammary cells into CD49f hi CD24 lo basal, CD49f med CD24 hi luminal progenitor, and CD49f lo CD24 hi mature luminal populations, resembling human breast, rather than mouse tissues. To elucidate their immediate radiation responses, we analyzed the mammary glands of female Sprague-Dawley rats, a radiation carcinogenesis model, using colony formation, flow cytometry and immunofluorescence. The mammary epithelium is maintained as two mostly independent lineages of luminal and basal cells. Breast tissue is very susceptible to radiation-induced carcinogenesis, and mammary stem/progenitor cells are potentially important targets of this.
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